Prof. Dr. Mine Öztürk Tonguç

HIDDEN DANGER IN OUR MOUTH FROM ALZHEIMER TO ANEMIA: PERIODONTAL INFLAMMATION

Periodontal diseases are chronic inflammatory diseases. Periodontal inflammation is carried to all tissues and organs in the body by bloodstream, which causing low-level, chronic systemic inflammation. Cellular mitochondrial damage, oxidative stress, metabolic inflammation and endothelial damage are caused by this chronic inflammation constitutes the common pathogenetic mechanism with cardio-metabolic, autoimmune and degenerative diseases associated with periodontal disease.

Today, many studies reveal that periodontal diseases are associated with many systemic diseases such as Type 2 Diabetes Mellitus, myocardial infarction, Alzheimer's disease, stroke, multiple sclerosis, Parkinson's disease and even sickle cell anemia characterized with chronic systemic inflammation.

Cardio-metabolic diseases progress with metabolic inflammation as a result of oxidative stress and mitochondrial damage in cells. Insulin resistance causes oxidative stress. Oxidative stress is seen as a key mechanism in the bidirectional relationship between periodontal diseases and chronic inflammatory diseases such as diabetes, metabolic syndrome, dyslipidemia and cardiovascular diseases. Oxidative damage and immune mechanisms play an important role in the pathogenesis of autoimmune diseases. Alzheimer's disease is a degenerative brain disease characterized by the accumulation of amyloid-B in neurons. It has been suggested that periodontal inflammation may also play a role in amyloid deposition in neurons.

In this presentation, the relationship of periodontal diseases with cardiometabolic, autoimmune, neurodegenerative diseases and blood diseases will be discussed.